| Sat, Feb 26, 2011 | 1:05 pm EST | Eagles @ Red Sox | City of Palms Park |
| Sat, Feb 26, 2011 | 6:00 pm EST | Huskies @ Red Sox | City of Palms Park |
| Sun, Feb 27, 2011 | 7:05 pm EST | Red Sox @ Twins | Hammond County Stadium |
| Mon, Feb 28, 2011 | 1:05 pm EST | Twins @ Red Sox | City of Palms Park |
| Tue, Mar 01, 2011 | 1:05 pm EST | Red Sox @ Twins | Hammond County Stadium |
| Wed, Mar 02, 2011 | 1:05 pm EST | Braves @ Red Sox | City of Palms Park |
| Thu, Mar 03, 2011 | 1:05 pm EST | Phillies @ Red Sox | City of Palms Park |
| Fri, Mar 04, 2011 | 7:05 pm EST | Red Sox @ Yankees | George M. Steinbrenner Field |
| Sat, Mar 05, 2011 | 1:05 pm EST | Red Sox @ Orioles | Ed Smith Stadium |
| Sat, Mar 05, 2011 | 1:05 pm EST | Marlins @ Red Sox | City of Palms Park |
| Sun, Mar 06, 2011 | 1:10 pm EST | Red Sox @ Mets | Digital Domain Park |
| Mon, Mar 07, 2011 | 1:05 pm EST | Orioles @ Red Sox | City of Palms Park |
| Tue, Mar 08, 2011 | 1:05 pm EST | Astros @ Red Sox | City of Palms Park |
| Tue, Mar 08, 2011 | 1:05 pm EST | Red Sox @ Cardinals | Roger Dean Stadium |
| Wed, Mar 09, 2011 | 7:05 pm EST | Orioles @ Red Sox | City of Palms Park |
| Thu, Mar 10, 2011 | 1:05 pm EST | Red Sox @ Rays | Charlotte Sports Park |
| Fri, Mar 11, 2011 | 1:05 pm EST | Red Sox @ Twins | Hammond County Stadium |
| Fri, Mar 11, 2011 | 1:05 pm EST | Red Sox @ Astros | Osceola County Stadium |
| Sat, Mar 12, 2011 | 1:05 pm EST | Marlins @ Red Sox | City of Palms Park |
| Sun, Mar 13, 2011 | 1:05 pm EDT | Red Sox @ Pirates | McKechnie Field |
| Mon, Mar 14, 2011 | 7:05 pm EDT | Yankees @ Red Sox | City of Palms Park |
| Tue, Mar 15, 2011 | 1:05 pm EDT | Red Sox @ Tigers | Joker Marchant Stadium |
| Wed, Mar 16, 2011 | 1:05 pm EDT | Red Sox @ Braves | Champion Stadium |
| Thu, Mar 17, 2011 | 1:05 pm EDT | Mets @ Red Sox | City of Palms Park |
| Fri, Mar 18, 2011 | 1:05 pm EDT | Tigers @ Red Sox | City of Palms Park |
| Fri, Mar 18, 2011 | 7:05 pm EDT | Red Sox @ Rays | Charlotte Sports Park |
| Sat, Mar 19, 2011 | 1:05 pm EDT | Red Sox @ Pirates | McKechnie Field |
| Sun, Mar 20, 2011 | 1:05 pm EDT | Cardinals @ Red Sox | City of Palms Park |
| Mon, Mar 21, 2011 | 1:05 pm EDT | Red Sox @ Phillies | Bright House Networks Field |
| Tue, Mar 22, 2011 | 7:05 pm EDT | Rays @ Red Sox | City of Palms Park |
| Thu, Mar 24, 2011 | 1:05 pm EDT | Red Sox @ Marlins | Roger Dean Stadium |
| Fri, Mar 25, 2011 | 7:05 pm EDT | Blue Jays @ Red Sox | City of Palms Park |
| Sat, Mar 26, 2011 | 7:05 pm EDT | Twins @ Red Sox | City of Palms Park |
| Sun, Mar 27, 2011 | 1:05 pm EDT | Red Sox @ Orioles | Ed Smith Stadium |
| Mon, Mar 28, 2011 | 1:05 pm EDT | Red Sox @ Blue Jays | Florida Auto Exchange Stadium |
| Tue, Mar 29, 2011 | 1:05 pm EDT | Rays @ Red Sox | City of Palms Park |
| Wed, Mar 30, 2011 | 7:05 pm CDT | Red Sox @ Astros | Minute Maid Park |
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